Sepsis, an Ancient Threat and Today's Challenge for Global Health

Abstract

Sepsis is a longstanding, deadly health issue affecting 49 million people and causing 11 million deaths annually, with stark disparities in care access between low- and high-income countries. Despite treatment advances, diagnosis and care remain challenging, and adherence to protocols varies widely. Survivors often face lasting health issues, especially in resource-limited regions where post-sepsis care is lacking. To address these gaps, the Global Sepsis Alliance’s 2030 agenda emphasizes political action, healthcare readiness, societal involvement, research, and preventive measures like sanitation and vaccination. Achieving a “world free of sepsis” depends on coordinated global efforts and expanded roles for healthcare workers.