A Conceptual Model of Sepsis as a Dysregulated Host Response: Depicting Directionality of Immunologic and Metabolic Dysregulation.

The OO(H)NO! Model

Authors

  • Julie Graham, PhD, APRN, ACCNS-AG San Diego State University
  • Elizabeth Scruth PhD MPH RN CNS CCRN-K CCNS FCCM FCNS CPHQ Kaiser Permanente

DOI:

https://doi.org/10.29173/ijcc78

Keywords:

sepsis, model, immunologic dysregulation, metabolic dysregulation

Abstract

Background

Mortality from Sepsis continues to remain high in hospitalized patients worldwide. Previously, the conceptual model of sepsis was based on the systemic inflammatory immune response syndrome, an adaptive model. In 2016, a new definition of sepsis was proposed as a dysregulated host response to infection, however until now, no model has been proposed elucidating what immunologic mechanisms are dysregulated.

Aim

We sought to propose a new model of sepsis to elucidate evidence-based immunologic and metabolic mechanisms which are dysregulated in sepsis.

Methods

Evidence in the literature comparing and contrasting sepsis before and after the 2016 consensus definition of sepsis was reviewed for themes. Themes from research published post 2016, were described connecting immunologic and metabolic mechanisms in sepsis. This information further informed earlier research that has been published by the primary author.

Results

A new conceptual model of sepsis was developed to elucidate the current definition of sepsis as a dysregulated host response, incorporating themes uncovered in sepsis research post 2016.

Conclusion

The model proposed here supports clinicians in applying the current definition of sepsis to a physiological model. This can benefit clinicians by offering new ways of recognizing sepsis, and researchers by recommending a physiologic model to advance sepsis research.

Keywords: Sepsis, sepsis model, immunologic dysregulation, metabolic dysregulation

Author Biographies

Julie Graham, PhD, APRN, ACCNS-AG, San Diego State University

Assistant Professor of Nursing, San Diego State University 

Elizabeth Scruth PhD MPH RN CNS CCRN-K CCNS FCCM FCNS CPHQ, Kaiser Permanente

Executive Director: Executive Director of Clinical Quality Programs, Data Analytics and Tele Critical Care, Kaiser Permanente Northern California, Department of Quality, Risk, Patient Safety

Downloads

Published

2024-11-01

How to Cite

Graham, J., & Scruth, E. (2024). A Conceptual Model of Sepsis as a Dysregulated Host Response: Depicting Directionality of Immunologic and Metabolic Dysregulation. : The OO(H)NO! Model. International Journal of Critical Care, 18(3), 7–21. https://doi.org/10.29173/ijcc78